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- August 25, 2003
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Sequence and variation data for Caenorhabditis elegans,
Drosophila melanogaster and Rattus norvegicus have been added to
the site. The human information has been updated to NCBI Build 33,
GenBank Release 133 and dbSNP Build 111.
- July 17, 2003
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Users with Premium Access now have access to a feature that can automatically
design amplicons for any number of exons in a gene with one command. (Premium
Access is available to customers with active support contracts. Please see
your Transgenomic sales representative for more information.)
- May 5, 2003
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Sequence and variation data for the mouse genome have been added to
the site. There have also been improvements in the workflow for DHPLC
analysis. For premium users a tool for melt analysis has been developed.
Several methods for calculating melt profiles and predicting melting
temperatures are combined into a single user interface to guide the initial
DHPLC oven temperature selection.
- March 18, 2003
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The site now has the ability to export mutationdiscovery.com amplicons for
use with Navigator™, Transgenomic's HPLC/DHPLC software for the
WAVE™ and WAVE-MD™ systems. Support has been added for
downloading a filtered list of variations in CSV format for a given locus. A
number of enhancements have been made to the sequence alignment
features.
- January 22, 2003
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Users are now able to share access to their features with groups of other
users they have designated. A new module for amplicon design has been
added for premium users. Regions of interest are indicated on a locus and
a simple user interface provides access to a Primer3 based algorithm for
generating the flanking primers. The resulting amplicon will be annotated
back onto the MutationDiscovery locus sequence.
- December 23, 2002
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Enhanced performance and functionality of the locus
sequence display. The system now supports multiple
gene models per locus (these alternative models will
show up over the course of the next few weeks as the
most recent NCBI releases are loaded). The interface
for selecting regions for annotating variations and
amplicons has been improved. A pop-up tool for
determining protocols for Optimase™-based PCR has
been added.
- September 15, 2002
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User variation and amplicon data entry is now supported,
allowing users to enter and share data with other registered
users as desired. Human pseudogene data has been added to
the site. Several enhancements,
including codon numbering on protein coding regions, locus
sequence searching using approximate string matching, and
export of locus genomic sequences, are also now available
on the site.
- July 24, 2002
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Enhanced gene and disease search from main page to search aliases
(e.g., searching for "PXE" now brings back ABCC6, even though "PXE"
exists only as a disease alias). Plus, several other minor fixes
and enhancements.
- July 8, 2002
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First public release of the site.
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